尿がん検査くんで測定しているDiAcSpm（ジアセチルスペルミン）については、世界中でがんとの関連が研究されており、多数の論文が発表されています。

これらの研究は、DiAcSpmという測定物質とがんの関連に関するものです。尿がん検査くんの結果だけで、がんの有無や部位を確定診断できることを示すものではありません。

尿がん検査くんは、現在のがんリスクを確認するためのスクリーニング検査としてご利用ください。

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主な論文

・Hiramatsu K, Sugimoto M, et al. “Diagnostic and prognostic usefulness of N1, N8-diacetylspermidine and N1, N12-diacetylspermine in urine as novel markers of malignancy.” J Cancer Res Clin Oncol. 123 (1997): 539–545.

・Enjoji M, Nakamuta M, et al. “Clinical significance of urinary N1, N12-diacetylspermine levels in patients with hepatocellular carcinoma.” Int J Biol Markers. 19(4) (2004): 322-327.

・Hiramatsu K, Takahashi K, et al. “N(1), N(12)-Diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers.” Clin Cancer Res. 11(8) (2005): 2986-2990.

・Yamaguchi K, Nakamura M, et al. “Urine diacetylspermine as a novel tumour maker for pancreatobiliary carcinomas.” Dig Liver Dis. 37(3) (2005): 190-194.

・Yoshifumi Umemori, Yui Ohe, et al. “Evaluating the utility of N1, N12-diacetylspermine and N1, N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers” Clinica Chimica Acta. 411(23-24) (2010): 1894-1899.

・Takahashi Y, Sakaguchi K, et al. “Urinary N1, N12-diacetylspermine is a non-invasive marker for the diagnosis and prognosis of non-small-cell lung cancer.” Br J Cancer. 113(10) (2015): 1493-1501.

・Niemi RJ, Roine AN, et al. “Urinary Polyamines as Biomarkers for Ovarian Cancer.” Int J Gynecol Cancer. 27(7) (2017): 1360-1366.

・Nakajima T, Katsumata K, et al. “Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls.” International Journal of Molecular Sciences. 19(3) (2018): 756.

・Deng L, Ismond K, et al. “Urinary Metabolomics to Identify a Unique Biomarker Panel for Detecting Colorectal Cancer: A Multicenter Study.” Cancer Epidemiol Biomarkers Prev. 28(8) (2019): 1283-1291.

・Yokota K, Hinoki A, et al. “Urinary N1, N12-diacetylspermine as a biomarker for pediatric cancer: a case-control study.” Pediatr Surg Int. 37(12) (2021): 1659-1665.

・DeFelice BC, Fiehn O, et al. “Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids.” Diagnostics. 12(4) (2022): 797.

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